Article
Abnormal craniofacial morphology and cartilage structure in transgenic mice harboring a Gly --> Cys mutation in the cartilage-specific type II collagen gene.
Journal of craniofacial genetics and developmental biology - 1 Jan 2000
Rintala M, Metsäranta M, Garofalo S, de Crombrugghe B, Vuorio E, Rönning O
Abstract excerpt
Gross morphology and histology of the craniofacial complex was studied in the offspring of two transgenic founder mice, Gly85-1 and Gly85-3, carrying several copies of a mouse type II collagen transgene that causes a single amino acid substitution (Gly-->Cys) at position 85 of the triple helix. The newborn transgenic mice had a short snout and mandible, a protruding tongue, a cleft of the secondary palate with...
Topics
- Animals
- Animals, Newborn
- Cartilage
- Collagen
- Cysteine
- Facial Bones
- Glycine
- Mice
- Mice, Transgenic
- Mutation
- Skull