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Article

Different isoforms of BSAP regulate expression of AID in normal and chronic lymphocytic leukemia B cells

24 Nov 2004

Abstract excerpt

Activation-induced cytidine deaminase (AID) is key to initiating somatic hypermutation (SHM) and class switch recombination (CSR), but its mode of action and regulation remains unclear. Since Pax-5 and Id-2 transcription factors play an opposing role in AID regulation, we have studied the expression of Pax-5, Id-2, and prdm-1 genes in 54 chronic lymphocytic leukemia (CLL) B cells. In 21 cases, presence of AID is...

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Identifiers

PMID: 15561888
DOI: 10.1182/blood-2004-09-3644

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