Article
Pharmacokinetics and resistance mutations affect virologic response to ritonavir/saquinavir-containing regimens.
Therapeutic drug monitoring - 1 Aug 2001
Pellegrin I, Breilh D, Birac V, Deneyrolles M, Mercié P, Trylesinski A, Neau D, Saux M C, Fleury H J, Pellegrin J L
Abstract excerpt
The authors assessed the impact of protease and reverse transcription (RT) mutations and individual pharmacokinetic parameters on virologic response to a four-drug regimen including ritonavir/saquinavir. Treatment was given at the start of the study (M0) to 22 HIV-1 protease inhibitor-naive or pretreated patients. Protease and RT genes were sequenced at M0, at the time of virologic failure, or at the end of the...
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