Article
HIV-1 genotypic resistance patterns predict response to saquinavir-ritonavir therapy in patients in whom previous protease inhibitor therapy had failed.
Annals of internal medicine - 7 Dec 1999
Zolopa A R, Shafer R W, Warford A, Montoya J G, Hsu P, Katzenstein D, Merigan T C, Efron B
Abstract excerpt
BACKGROUND: Tests for resistance to HIV drugs are available for clinical use; however, their predictive value has not been fully assessed. OBJECTIVES: To determine HIV-1 genotypic predictors of a virologic response to saquinavir-ritonavir therapy in patients in whom at least one previous protease...
Topics
- Adult
- CD4 Lymphocyte Count
- Cohort Studies
- Drug Resistance, Microbial
- Drug Therapy, Combination
- Endopeptidases
- Female
- Genotype
- HIV Infections
- HIV Protease Inhibitors
- HIV-1
- Humans
- Linear Models
- Male