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Article

Association of amino acid sequences in the HLA-DQB1 first domain with antitopoisomerase I autoantibody response in scleroderma (progressive systemic sclerosis).

The Journal of clinical investigation - 1 Sept 1992

Reveille J D, Durban E, MacLeod-St Clair M J, Goldstein R, Moreda R, Altman R D, Arnett F C

Abstract excerpt

Previous studies in Caucasians with progressive systemic sclerosis (PSS) have suggested associations of antitopoisomerase I (antitopo I) autoantibodies with either serologically defined HLA-DR2 or DR5. To better define class II HLA associations with the antitopo I response, 161 PSS patients (132 Caucasians and 29 American blacks) were studied for antitopo I autoantibodies by immunodiffusion and immunoblotting,...

Topics

Alleles
Amino Acid Sequence
Autoantibodies
Base Sequence
Black People
DNA Topoisomerases, Type I
Gene Frequency
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DR Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Scleroderma, Systemic

White People

Source

Open in PubMed Open full text

Identifiers

PMID: 1326003
DOI: 10.1172/JCI115974
PMCID: PMC329953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1326003-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Association of amino acid sequences in the HLA-DQB1 first domain with antitopoisomerase I autoantibody response in scleroderma (progressive systemic sclerosis).PMID 1326003Read ↗

Association of polar amino acids at position 26 of the HLA-DQB1 first domain with the anticentromere autoantibody response in systemic sclerosis (scleroderma).Semantic proximity Read ↗

Association of HLA-DR with progressive systemic sclerosis in Japanese.Semantic proximity Read ↗

Different distribution of HLA class II alleles in anti-topoisomerase I autoantibody responders between silicosis and systemic sclerosis patients, with a common distinct amino acid sequence in the HLA-DQB1 domain.Semantic proximity Read ↗

HLA and autoimmunity in scleroderma (systemic sclerosis).Semantic proximity Read ↗

MHC class II associations with autoantibody and T cell immune responses to the scleroderma autoantigen topoisomerase I.Semantic proximity Read ↗

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HLA-DQB1 associations with anti-topoisomerase-1 antibodies in patients with systemic sclerosis and their first degree relatives. United Kingdom Systemic Sclerosis Study Group.Semantic proximity Read ↗

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HLA class II genes associated with anticentromere antibody in Japanese patients with systemic sclerosis (scleroderma).Semantic proximity Read ↗

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