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Article

The amino acid variation within the binding pocket 7 and 9 of HLA-DRB1 molecules are associated with primary Sjögren's syndrome.

Journal of autoimmunity - 1 Feb 2015

Huang Renliang, Yin Junping, Chen Yan, Deng Fengyuan, Chen Juan, Gao Xing, Liu Zuguo, Yu Xinhua, Zheng Junfeng

Abstract excerpt

Primary Sjögren's syndrome (pSS) is associated with HLA-DRB1 loci, but the association of amino acid variations in the hypervariable region of the HLA-DR β1 chain with pSS is largely unknown. In this study, we aimed to identify the amino acid variations within the hypervariable region of HLA-DRB1 molecule which are associated with the susceptibility to pSS. We sequenced the 2nd exon of the HLA-DRB1 locus in...

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Identifiers

PMID: 25582848
DOI: 10.1016/j.jaut.2014.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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