Article
Mevinolin-resistant mutations identify a promoter and the gene for a eukaryote-like 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the archaebacterium Haloferax volcanii.
The Journal of biological chemistry - 25 Mar 1992
Lam W L, Doolittle W F
Abstract excerpt
Both eukaryotes and archaebacteria use 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase to synthesize mevalonate, which eukaryotes employ in the production of sterols and archaebacteria need for the isoprenoid side chains of their unique and characteristic lipids. The drug mevinolin inhibits HMG-CoA reductase in eukaryotes and in the halophilic archaebacteria, and we have used a spontaneous mutation to...
Topics
- Amino Acid Sequence
- Animals
- Archaea
- Base Sequence
- Cricetinae
- DNA, Bacterial
- Genes, Bacterial
- Halobacterium
- Hydroxymethylglutaryl CoA Reductases
- Kinetics
- Lovastatin