Article
An unusual pattern of spontaneous mutations recovered in the halophilic archaeon Haloferax volcanii.
Genetics - 1 May 2007
Mackwan Reena R, Carver Geraldine T, Drake John W, Grogan Dennis W
Abstract excerpt
Spontaneous mutations in the orotate:phosphoribosyl transferase (pyrE2) gene of the halophilic archaeon Haloferax volcanii were selected by 5-fluoroorotic acid plus uracil at a rate of approximately 2 x 10(-8)/cell division in fluctuation and null-fraction tests but approximately 6 x 10(-8)/cell division in mutation-accumulation tests. The corresponding genomic mutation rates were substantially lower than those...
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