Article
The genetic epidemiology of breast cancer genes.
Journal of mammary gland biology and neoplasia - 1 Jul 2004
Thompson Deborah, Easton Douglas
Abstract excerpt
Genetic susceptibility to breast cancer in women is conferred by a large number of genes, of which six have so far been identified. In the context of multiple-case families, BRCA1 and BRCA2 are the most important. Mutations in these genes confer high lifetime risks of breast cancer and ovarian cancer, and more moderate risks of prostate cancer and some other cancer types. Mutations in the CHEK2 and ATM genes, by...
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