Article
Common breast cancer risk variants in the post-COGS era: a comprehensive review.
Breast cancer research : BCR - 20 Dec 2013
Maxwell Kara N, Nathanson Katherine L
Abstract excerpt
Breast cancer has a strong heritable component, with approximately 15% of cases exhibiting a family history of the disease. Mutations in genes such as BRCA1, BRCA2 and TP53 lead to autosomal dominant inherited cancer susceptibility and confer a high lifetime risk of breast cancers. Identification of mutations in these genes through clinical genetic testing enables patients to undergo screening and prevention...
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