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Article

Common breast cancer risk variants in the post-COGS era: a comprehensive review.

Breast cancer research : BCR - 20 Dec 2013

Maxwell Kara N, Nathanson Katherine L

Abstract excerpt

Breast cancer has a strong heritable component, with approximately 15% of cases exhibiting a family history of the disease. Mutations in genes such as BRCA1, BRCA2 and TP53 lead to autosomal dominant inherited cancer susceptibility and confer a high lifetime risk of breast cancers. Identification of mutations in these genes through clinical genetic testing enables patients to undergo screening and prevention...

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Identifiers

PMID: 24359602
DOI: 10.1186/bcr3591
PMCID: PMC3978855

Genes

ATM
BRCA1
BRCA2
BRIP1
CHEK2
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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