Article
Inherited mutations in breast cancer genes--risk and response.
Journal of mammary gland biology and neoplasia - 1 Apr 2011
Shuen Andrew Y, Foulkes William D
Abstract excerpt
Germ-line mutations in BRCA1 and BRCA2 confer a high risk of developing breast cancer. They account, however, for only 40% of strongly familial breast cancer cases. Intensive genome-wide searches for other highly-penetrant BRCA genes that, individually account for a sizeable fraction of the remaining heritability has not identified any plausible candidates. The "missing heritability" is thought to be due to...
Topics
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- DNA Damage
- Female
- Genes, BRCA1
- Genes, BRCA2
- Genetic Predisposition to Disease
- Humans
- Mutation