Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inherited mutations in breast cancer genes--risk and response.

Journal of mammary gland biology and neoplasia - 1 Apr 2011

Shuen Andrew Y, Foulkes William D

Abstract excerpt

Germ-line mutations in BRCA1 and BRCA2 confer a high risk of developing breast cancer. They account, however, for only 40% of strongly familial breast cancer cases. Intensive genome-wide searches for other highly-penetrant BRCA genes that, individually account for a sizeable fraction of the remaining heritability has not identified any plausible candidates. The "missing heritability" is thought to be due to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to BRCA2 Protein
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Damage

Share to Genes, BRCA1

Share to Genes, BRCA2

Share to Genetic Predisposition to Disease

Share to Mutation

Source

Identifiers

PMID: 21461995
DOI: 10.1007/s10911-011-9213-5

Genes

BRCA1
BRCA2
ATM
BRIP1
CHEK2
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inherited mutations in breast cancer genes--risk and response.PMID 21461995Read ↗

Genetic predisposition to breast cancer: past, present, and future.Semantic proximity Read ↗

Genetic risk of breast cancer.Semantic proximity Read ↗

Breast cancer genes: beyond BRCA1 and BRCA2.Semantic proximity Read ↗

Functions of Breast Cancer Predisposition Genes: Implications for Clinical Management.Semantic proximity Read ↗

Hereditary breast cancer: the era of new susceptibility genes.Semantic proximity Read ↗

The genetic epidemiology of breast cancer genes.Semantic proximity Read ↗

Breast cancer susceptibility: current knowledge and implications for genetic counselling.Semantic proximity Read ↗

Genetics of breast cancer: a topic in evolution.Semantic proximity Read ↗

Women at high risk of breast cancer: Molecular characteristics, clinical presentation and management.Semantic proximity Read ↗

Genetic susceptibility to breast cancer.Semantic proximity Read ↗

Genetic Predisposition to Breast and Ovarian Cancers: How Many and Which Genes to Test?Semantic proximity Read ↗

Comparison of Patient Susceptibility Genes Across Breast Cancer: Implications for Prognosis and Therapeutic OutcomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.