Gene-gene interactions in breast cancer susceptibility.

doi:10.1093/hmg/ddr525

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Article

Gene-gene interactions in breast cancer susceptibility.

Human molecular genetics - 15 Feb 2012

Turnbull Clare, Seal Sheila, Renwick Anthony, Warren-Perry Margaret, Hughes Deborah, Elliott Anna, Pernet David, Peock Susan, Adlard Julian W, Barwell Julian, Berg Jonathan, Brady Angela F, Brewer Carole, Brice Glen, Chapman Cyril, Cook Jackie, Davidson Rosemarie, Donaldson Alan, Douglas Fiona, Greenhalgh Lynn, Henderson Alex, Izatt Louise, Kumar Ajith, Lalloo Fiona, Miedzybrodzka Zosia, Morrison Patrick J, Paterson Joan, Porteous Mary, Rogers Mark T, Shanley Susan, Walker Lisa, Ahmed Munaza, Eccles Diana, Evans D Gareth, Donnelly Peter, Easton Douglas F, Stratton Michael R, Rahman Nazneen

Abstract excerpt

There have been few definitive examples of gene-gene interactions in humans. Through mutational analyses in 7325 individuals, we report four interactions (defined as departures from a multiplicative model) between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2 (case-only interaction between ATM and BRCA1/BRCA2 combined, P = 5.9 × 10(-4); ATM and BRCA1, P= 0.01; ATM and...

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Identifiers

PMID: 22072393
DOI: 10.1093/hmg/ddr525
PMCID: PMC4125627

Genes

BRCA1
BRCA2
ATM
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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