Article
Genetic predisposition to breast cancer: past, present, and future.
Annual review of genomics and human genetics - 1 Jan 2008
Turnbull Clare, Rahman Nazneen
Abstract excerpt
In recent years, our understanding of genetic predisposition to breast cancer has advanced significantly. Three classes of predisposition factors, categorized by their associated risks of breast cancer, are currently known. BRCA1 and BRCA2 are high-penetrance breast cancer predisposition genes identified by genome-wide linkage analysis and positional cloning. Mutational screening of genes functionally related to...
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