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Article

A mutant of Mycobacterium tuberculosis H37Rv that lacks expression of antigen 85A is attenuated in mice but retains vaccinogenic potential.

Infection and immunity - 1 Dec 2004

Copenhaver Robert H, Sepulveda Eliud, Armitige Lisa Y, Actor Jeffrey K, Wanger Audrey, Norris Steven J, Hunter Robert L, Jagannath Chinnaswamy

Abstract excerpt

The fbpA and fbpB genes encoding the 85A and 85B proteins of Mycobacterium tuberculosis H37Rv, respectively, were disrupted, the mutants were examined for their ability to survive, and the strain lacking 85A (DeltafbpA) was tested for its ability to immunize mice. The DeltafbpA mutant was attenuated in mice after intravenous or aerosol infection, while replication of the DeltafbpB mutant was similar to that of...

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Identifiers

PMID: 15557632
DOI: 10.1128/IAI.72.12.7084-7095.2004
PMCID: PMC529100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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