Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunization of mice with a recombinant adenovirus vaccine inhibits the early growth of Mycobacterium tuberculosis after infection.

PloS one - 9 Dec 2009

Ronan Edward O, Lee Lian Ni, Beverley Peter C L, Tchilian Elma Z

Abstract excerpt

BACKGROUND: In pulmonary Mycobacterium tuberculosis (Mtb) infection, immune responses are delayed compared to other respiratory infections, so that antigen-specific cells are not detected in the lungs earlier than day 14. Even after parenteral immunization with Bacille Calmette Guerin (BCG) or a subunit vaccine, the immune response after Mtb challenge is only slightly accelerated and the kinetics of pulmonary Mtb...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Administration, Intranasal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antigens, Bacterial

Share to Epitopes

Share to Immunity

Share to Tuberculosis, Pulmonary

Share to Vaccination

Share to Vaccines, Synthetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20011050
DOI: 10.1371/journal.pone.0008235
PMCID: PMC2785469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunization of mice with a recombinant adenovirus vaccine inhibits the early growth of Mycobacterium tuberculosis after infection.PMID 20011050Read ↗

Investigation of pre-existing mycobacterial immunity on the immunogenicity and efficacy of new TB vaccinesSemantic proximity Read ↗

A Human Type 5 Adenovirus–Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti-Adenovirus ImmunitySemantic proximity Read ↗

A recombinant adenovirus expressing immunodominant TB antigens can significantly enhance BCG-induced human immunitySemantic proximity Read ↗

A mutant of Mycobacterium tuberculosis H37Rv that lacks expression of antigen 85A is attenuated in mice but retains vaccinogenic potential.Semantic proximity Read ↗

Safety and immunopotency of an adenovirus-vectored tuberculosis vaccine delivered via inhaled aerosol to healthy humans: a dose and route comparison phase 1b studySemantic proximity Read ↗

Protection against Tuberculosis with Homologous or Heterologous Protein/Vector Vaccine Approaches Is Not Dependent on CD8+ T CellsSemantic proximity Read ↗

Induction of an Immune-Protective T-Cell Repertoire With Diverse Genetic Coverage by a Novel Viral-Vectored Tuberculosis Vaccine in HumansSemantic proximity Read ↗

Replication-deficient Adenovirus 5 Serotypes Induce Type I Interferon and enhance BCG-mediated Immune Response in Co-infected Murine MacrophagesSemantic proximity Read ↗

Tuberculosis vaccines: current progress.Semantic proximity Read ↗

Improving vaccines against tuberculosisSemantic proximity Read ↗

Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trialsSemantic proximity Read ↗

Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.