Article
The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice.
Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 2003
Dahl John L, Kraus Carl N, Boshoff Helena I M, Doan Bernard, Foley Korrie, Avarbock David, Kaplan Gilla, Mizrahi Valerie, Rubin Harvey, Barry Clifton E
Abstract excerpt
Long-term survival of nonreplicating Mycobacterium tuberculosis (Mtb) is ensured by the coordinated shutdown of active metabolism through a broad transcriptional program called the stringent response. In Mtb, this response is initiated by the enzymatic action of RelMtb and deletion of relMtb produces a strain (H37RvDeltarelMtb) severely compromised in the maintenance of long-term viability. Although aerosol...
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