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Article

Early and quantal (by litter) expression of insulin autoantibodies in the nonobese diabetic mice predict early diabetes onset.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2004

Melanitou Evie, Devendra Devasenan, Liu Edwin, Miao Dongmei, Eisenbarth George S

Abstract excerpt

Aiming to study the early stages of type 1 diabetes phenotype, before insulitis appears, we measured insulin autoantibodies (IAA) between 3 and 5 wk of age in the NOD mouse (early-IAA (E-IAA)). We report that IAA are found as early as at 3 wk of age, at weaning, and their expression is a quantal phenotype. Maternal autoantibody status influences this early phenotype, because animals of litters issued from...

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Source

Identifiers

PMID: 15557150
DOI: 10.4049/jimmunol.173.11.6603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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