Article
Sodium-lithium countertransport and the Gly460-->Trp alpha-adducin polymorphism in essential hypertension.
Clinical science (London, England : 1979) - 1 Mar 2005
Mead Paul A, Harvey John N, Rutherford Peter A, Leitch Helen, Thomas Trevor H
Abstract excerpt
A polymorphism of the alpha-subunit of adducin, Gly460-->Trp, may affect membrane ion transport and be associated with human EH (essential hypertension). The alpha-adducin Gly460-->Trp polymorphism was determined in 242 NC (normal controls) and 73 patients with EH and was related to the membrane ion transport marker in EH, erythrocyte Na/LiCT (sodium-lithium countertransport), in a subgroup of these subjects. The...
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