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Article

alpha-Adducin 460Trp allele is associated with erythrocyte Na transport rate in North Sardinian primary hypertensives.

Hypertension (Dallas, Tex. : 1979) - 1 Feb 2002

Glorioso Nicola, Filigheddu Fabiana, Cusi Daniele, Troffa Chiara, Conti Milena, Natalizio Marcella, Argiolas Giuseppe, Barlassina Cristina, Bianchi Giuseppe

Abstract excerpt

Erythrocyte membrane alterations mirror those of vascular smooth muscle and renal tubular cell membrane. The interaction between adducin and Na-K pump is the most likely biochemical mechanism responsible for the increased tubular Na reabsorption and hypertension in Milan hypertensive strain (MHS) rats. To substantiate this hypothesis in humans, we tested to see if alpha-adducin Gly460Trp genotype is associated...

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PMID: 11882573
DOI: 10.1161/hy0202.103065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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