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Article

Longitudinal analysis of nef/long terminal repeat-deleted HIV-1 in blood and cerebrospinal fluid of a long-term survivor who developed HIV-associated dementia.

The Journal of infectious diseases - 15 Dec 2004

Churchill Melissa, Sterjovski Jasminka, Gray Lachlan, Cowley Daniel, Chatfield Catherine, Learmont Jennifer, Sullivan John S, Crowe Suzanne M, Mills John, Brew Bruce J, Wesselingh Steven L, McPhee Dale A, Gorry Paul R

Abstract excerpt

We studied the evolution and compartmentalization of nef/long terminal repeat (nef/LTR)-deleted human immunodeficiency virus type 1 (HIV-1) from a long-term survivor who developed HIV-associated dementia (HIVD). Analysis of sequential blood-derived HIV-1 isolated before and during HIVD revealed a persistent R5X4 phenotype and a progressive loss of nef/LTR sequence; in contrast, HIV-1 present in cerebrospinal...

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PMID: 15551218
DOI: 10.1086/425585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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