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Article

HIV-1 replication in the central nervous system occurs in two distinct cell types.

PLoS pathogens - 1 Oct 2011

Schnell Gretja, Joseph Sarah, Spudich Serena, Price Richard W, Swanstrom Ronald

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) can lead to the development of HIV-1-associated dementia (HAD). We examined the virological characteristics of HIV-1 in the cerebrospinal fluid (CSF) of HAD subjects to explore the association between independent viral replication in the CNS and the development of overt dementia. We found that genetically compartmentalized...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22007152
DOI: 10.1371/journal.ppat.1002286
PMCID: PMC3188520

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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