Article
Compartmentalization and clonal amplification of HIV-1 variants in the cerebrospinal fluid during primary infection.
Journal of virology - 1 Mar 2010
Schnell Gretja, Price Richard W, Swanstrom Ronald, Spudich Serena
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) is a severe neurological disease that affects a subset of HIV-1-infected individuals. Increased compartmentalization has been reported between blood and cerebrospinal fluid (CSF) HIV-1 populations in subjects with HAD, but it is still not known when compartmentalization arises during the course of infection. To assess HIV-1 genetic...
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