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Article

Compartmentalized human immunodeficiency virus type 1 originates from long-lived cells in some subjects with HIV-1-associated dementia.

PLoS pathogens - 1 Apr 2009

Schnell Gretja, Spudich Serena, Harrington Patrick, Price Richard W, Swanstrom Ronald

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) shortly after systemic infection and can result in the subsequent development of HIV-1-associated dementia (HAD) in a subset of infected individuals. Genetically compartmentalized virus in the CNS is associated with HAD, suggesting autonomous viral replication as a factor in the disease process. We examined the source of...

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Identifiers

PMID: 19390619
DOI: 10.1371/journal.ppat.1000395
PMCID: PMC2668697

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Source receipt: pubmed, retrieved 7 Sept 2026.

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