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Article

Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression.

Oncotarget - 20 Mar 2015

Valenti Fabio, Ganci Federica, Fontemaggi Giulia, Sacconi Andrea, Strano Sabrina, Blandino Giovanni, Di Agostino Silvia

Abstract excerpt

Genomic instability (IN) is a common feature of many human cancers. The TP53 tumour suppressor gene is mutated in approximately half of human cancers. Here, we show that BRCA1 and RAD17 genes, whose derived proteins play a pivotal role in DNA damage repair, are transcriptional targets of gain-of-...

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Source

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Identifiers

PMID: 25650659
DOI: 10.18632/oncotarget.2587
PMCID: PMC4467386

Genes

BRCA1
RAD17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25650659-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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