Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of the effect of mutant and wild-type p53 on global gene expression.

Cancer research - 15 Nov 2004

O'Farrell Thomas J, Ghosh Paritosh, Dobashi Nobuaki, Sasaki Carl Y, Longo Dan L

Abstract excerpt

The mechanisms for "gain-of-function" phenotypes produced by mutant p53s such as enhanced proliferation, resistance to transforming growth factor-beta-mediated growth suppression, and increased tumorigenesis are not known. One theory is that these phenotypes are caused by novel transcriptional regulatory events acquired by mutant p53s. Another explanation is that these effects are a result of an imbalance of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Line, Tumor
Share to DNA Primers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to Mutation

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 15548685
DOI: 10.1158/0008-5472.CAN-03-3639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparison of the effect of mutant and wild-type p53 on global gene expression.PMID 15548685Read ↗

Transcription regulation by mutant p53.Semantic proximity Read ↗

Differentially expressed downstream genes in cells with normal or mutated p53.Semantic proximity Read ↗

Transcriptional activities of mutant p53: when mutations are more than a loss.Semantic proximity Read ↗

Identification of GRO1 as a critical determinant for mutant p53 gain of function.Semantic proximity Read ↗

Mutant p53 regulates a distinct gene set by a mode of genome occupancy that is shared with wild type.Semantic proximity Read ↗

Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity.Semantic proximity Read ↗

Transactivation of the EGR1 gene contributes to mutant p53 gain of function.Semantic proximity Read ↗

Inhibition of HIF-1- and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions.Semantic proximity Read ↗

Modulation of Gene Expression by Tumor-Derived p53 MutantsSemantic proximity Read ↗

p53 induces distinct epigenetic states at its direct target promoters.Semantic proximity Read ↗

A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model.Semantic proximity Read ↗

Differential modulation of cellular and viral promoters by p73 and p53.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.