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Article

Comparison of the effect of mutant and wild-type p53 on global gene expression.

Cancer research - 15 Nov 2004

O'Farrell Thomas J, Ghosh Paritosh, Dobashi Nobuaki, Sasaki Carl Y, Longo Dan L

Abstract excerpt

The mechanisms for "gain-of-function" phenotypes produced by mutant p53s such as enhanced proliferation, resistance to transforming growth factor-beta-mediated growth suppression, and increased tumorigenesis are not known. One theory is that these phenotypes are caused by novel transcriptional re...

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PMID: 15548685
DOI: 10.1158/0008-5472.CAN-03-3639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15548685-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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