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Article

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions.

FEBS letters - 1 Apr 2026

Metcalf Stephanie A, Downing Nicholas F, Mills Kaitlyn M, Metcalfe Samuel C, Kritzer Alexander E, Mayo Lindsey D, Hollenhorst Peter C

Abstract excerpt

ETS family transcription factors can mediate mutant p53 functions, but there has been no comprehensive analysis of p53 interaction across the ETS family. By comparing direct mutant p53 binding between 26 ETS proteins, we found that all bound mutant p53, but relative binding differed significantly. The ETS DNA binding domain provided a common interaction interface, but strong binding required an alternate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41473985
DOI: 10.1002/1873-3468.70260
PMCID: PMC13113215

Genes

ERG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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