Article
Interrogating congenital heart defects with noninvasive fetal echocardiography in a mouse forward genetic screen.
Circulation. Cardiovascular imaging - 1 Jan 2014
Liu Xiaoqin, Francis Richard, Kim Andrew J, Ramirez Ricardo, Chen Guozhen, Subramanian Ramiah, Anderton Shane, Kim Youngsil, Wong Liyin, Morgan Judy, Pratt Herbert C, Reinholdt Laura, Devine William, Leatherbury Linda, Tobita Kimimasa, Lo Cecilia W
Abstract excerpt
BACKGROUND: Congenital heart disease (CHD) has a multifactorial pathogenesis, but a genetic contribution is indicated by heritability studies. To investigate the spectrum of CHD with a genetic pathogenesis, we conducted a forward genetic screen in inbred mice using fetal echocardiography to recover mutants with CHD. Mice are ideally suited for these studies given that they have the same four-chamber cardiac...
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