Evidence of a dominant negative mutant of yeast methionine aminopeptidase type 2 in Saccharomyces cerevisiae.

doi:10.1002/jcb.20285

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Article

Evidence of a dominant negative mutant of yeast methionine aminopeptidase type 2 in Saccharomyces cerevisiae.

Journal of cellular biochemistry - 1 Mar 2005

Vetro Joseph A, Dummitt Benjamin, Micka William S, Chang Yie-Hwa

Abstract excerpt

Eukaryotic methionine aminopeptidase type 2 (MetAP2, MetAP2 gene (MAP2)), together with eukaryotic MetAP1, cotranslationally hydrolyzes initiator methionine from nascent polypeptides when the side chain of the second residue is small and uncharged. In this report, we took advantage of the yeast (Saccharomyces cerevisiae) map1 null strain's reliance on MetAP2 activity for the growth and viability to provide...

Topics

Aminopeptidases
Catalysis
Cell Survival
Gene Expression Regulation, Fungal
Genes, Dominant
Histidine
Metalloendopeptidases
Mutation
Promoter Regions, Genetic
Saccharomyces cerevisiae

Source

Open in PubMed

Identifiers

PMID: 15547949
DOI: 10.1002/jcb.20285

Genes

MAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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