N-terminal methionine removal and methionine metabolism in Saccharomyces cerevisiae.

doi:10.1002/jcb.10566

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Article

N-terminal methionine removal and methionine metabolism in Saccharomyces cerevisiae.

Journal of cellular biochemistry - 1 Aug 2003

Dummitt Benjamin, Micka William S, Chang Yie-Hwa

Abstract excerpt

Methionine aminopeptidase (MetAP) catalyzes removal of the initiator methionine from nascent polypeptides. In eukaryotes, there are two forms of MetAP, type 1 and type 2, whose combined activities are essential, but whose relative intracellular roles are unclear. Methionine metabolism is an important aspect of cellular physiology, involved in oxidative stress, methylation, and cell cycle. Due to the potential of...

Topics

Aminopeptidases
DNA-Binding Proteins
Gene Expression Regulation, Enzymologic
Genes, Fungal
Genotype
Humans
Isoenzymes
Methionine
Methionyl Aminopeptidases
Mutagenesis
Saccharomyces cerevisiae
Substrate Specificity
beta-Galactosidase

Source

Open in PubMed

Identifiers

PMID: 12874831
DOI: 10.1002/jcb.10566

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