Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene expression in humans with diabetes and prediabetes: what have we learned about diabetes pathophysiology?

Current opinion in clinical nutrition and metabolic care - 1 Jul 2004

Patti Mary-Elizabeth

Abstract excerpt

PURPOSE OF REVIEW: Type 2 diabetes mellitus is characterized by insulin resistance and pancreatic beta-cell dysfunction. In high-risk individuals, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, and glycogen synthesis, and the accumulation of intramyocellular triglycerides have all been linked with insulin resistance, but no...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to Energy Metabolism
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin Resistance

Share to Islets of Langerhans

Share to Peroxisome Proliferator-Activated Receptors

Share to Prediabetic State

Share to Transcription Factors

Source

Identifiers

PMID: 15192439
DOI: 10.1097/01.mco.0000134359.23288.72

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene expression in humans with diabetes and prediabetes: what have we learned about diabetes pathophysiology?PMID 15192439Read ↗

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.Semantic proximity Read ↗

Genes and pathophysiology of type 2 diabetes: more than just the Randle cycle all over again.Semantic proximity Read ↗

Genetic underpinnnings of type 2 diabetes.Semantic proximity Read ↗

Please pass the chips: genomic insights into obesity and diabetes.Semantic proximity Read ↗

Gene expression profile in obesity and type 2 diabetes mellitusSemantic proximity Read ↗

Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits.Semantic proximity Read ↗

Mitochondrial gene expression in diabetes mellitus: effect of nutrition.Semantic proximity Read ↗

A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance.Semantic proximity Read ↗

Nutrition-/diet-induced changes in gene expression in pancreatic β-cells.Semantic proximity Read ↗

Global Gene Expression Profiles of Subcutaneous Adipose and Muscle From Glucose-Tolerant, Insulin-Sensitive, and Insulin-Resistant Individuals Matched for BMISemantic proximity Read ↗

Physiological insights gained from gene expression analysis in obesity and diabetes.Semantic proximity Read ↗

Epigenomic and transcriptional control of insulin resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.