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Article

Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes

1 Feb 2010

Abstract excerpt

BACKGROUND: Skeletal muscle insulin resistance (IR) is considered a critical component of type II diabetes, yet to date IR has evaded characterization at the global gene expression level in humans. MicroRNAs (miRNAs) are considered fine-scale rheostats of protein-coding gene product abundance. The relative importance and mode of action of miRNAs in human complex diseases remains to be fully elucidated. We produce...

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PMID: 20353613
DOI: 10.1186/gm130

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