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Article

Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes

25 May 2017

Abstract excerpt

BACKGROUND: Skeletal muscle is one of the primary tissues involved in the development of type 2 diabetes (T2D). The close association between obesity and T2D makes it difficult to isolate specific effects attributed to the disease alone. Therefore, here we set out to identify and characterize intrinsic properties of myocytes, associated independently with T2D or obesity. METHODS: We generated and analyzed RNA-seq...

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PMID: 28545587
DOI: 10.1186/s13073-017-0432-2

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