Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis.

Molecular and cellular biology - 1 Dec 2004

Piazza Francesco, Costoya José A, Merghoub Taha, Hobbs Robin M, Pandolfi Pier Paolo

Abstract excerpt

Deregulated function of members of the POK (POZ and Kruppel) family of transcriptional repressors, such as promyelocytic leukemia zinc finger (PLZF) and B-cell lymphoma 6 (BCL-6), plays a critical role in the pathogenesis of acute promyelocytic leukemia (APL) and non-Hodgkin's lymphoma, respectively. PLZP, also known as TZFP, FAZF, or ROG, is a novel POK protein that displays strong homology with PLZF and has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD3 Complex
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Separation

Share to Fanconi Anemia

Share to Hematopoietic Stem Cells

Share to Lac Operon

Share to Ribonucleases

Share to Testis

Source

Open in PubMed Open full text

Identifiers

PMID: 15542853
DOI: 10.1128/MCB.24.23.10456-10469.2004
PMCID: PMC529048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis.PMID 15542853Read ↗

POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and functionSemantic proximity Read ↗

Deletion of the Miz-1 POZ Domain Increases Efficacy of Cytarabine Treatment in T- and B-ALL/Lymphoma Mouse ModelsSemantic proximity Read ↗

PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression.Semantic proximity Read ↗

The Promyelocytic Leukemia Zinc Finger Protein: Two Decades of Molecular OncologySemantic proximity Read ↗

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.Semantic proximity Read ↗

Embryonic defects and growth alteration in mice with homozygous disruption of the Patz1 gene.Semantic proximity Read ↗

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemiaSemantic proximity Read ↗

POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin ExpressionSemantic proximity Read ↗

Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.Semantic proximity Read ↗

Members of the <i>Plag</i> gene family are expressed in complementary and overlapping regions in the developing murine nervous systemSemantic proximity Read ↗

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.Semantic proximity Read ↗

An allele separating skeletal patterning and spermatogonial renewal functions of PLZF.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.