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Article

The Promyelocytic Leukemia Zinc Finger Protein: Two Decades of Molecular Oncology

1 Jan 2012

Abstract excerpt

The promyelocytic leukemia zinc finger (PLZF) protein, also known as Zbtb16 or Zfp145, was first identified in a patient with acute promyelocytic leukemia, where a reciprocal chromosomal translocation t(11;17)(q23;q21) resulted in a fusion with the RARA gene encoding retinoic acid receptor alpha. The wild-type Zbtb16 gene encodes a transcription factor that belongs to the POK (POZ and Krüppel) family of...

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PMID: 22822476
DOI: 10.3389/fonc.2012.00074

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