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Article

Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.

Molecular and cellular biology - 1 Dec 2004

Alpatov Roman, Munguba Gustavo Costa, Caton Paul, Joo Jeong Hoon, Shi Yang, Shi Yujiang, Hunt Marguerite E, Sugrue Stephen P

Abstract excerpt

Previously, we have shown that pinin/DRS (Pnn), a 140-kDa nuclear and cell adhesion-related phosphoprotein, is involved in the regulation of cell adhesion and modulation of the activity of multiple tumor suppressor genes. In the nucleus Pnn is concentrated in the "nuclear speckles," zones of accumulation of transcriptional and mRNA splicing factors, where Pnn is involved in mRNA processing. Alternatively, other...

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Identifiers

PMID: 15542832
DOI: 10.1128/MCB.24.23.10223-10235.2004
PMCID: PMC529029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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