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Article

Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors.

Molecular and cellular biology - 1 Dec 2004

Kim Tae-Gyun, Chen Junqin, Sadoshima Junich, Lee Youngsook

Abstract excerpt

Mice with a homozygous knockout of the jumonji (jmj) gene showed abnormal heart development and defective regulation of cardiac-specific genes, including the atrial natriuretic factor (ANF). ANF is one of the earliest markers of cardiac differentiation and a hallmark for cardiac hypertrophy. Here, we show that JMJ represses ANF gene expression by inhibiting transcriptional activities of Nkx2.5 and GATA4. JMJ...

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Share to Atrial Natriuretic Factor
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homeobox Protein Nkx-2.5

Share to Immunoprecipitation

Share to Myocardium

Share to Myocytes, Cardiac

Share to Polycomb Repressive Complex 2

Share to Protein Biosynthesis

Source

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Identifiers

PMID: 15542826
DOI: 10.1128/MCB.24.23.10151-10160.2004
PMCID: PMC529025

Genes

GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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