Article
jumonji downregulates cardiac cell proliferation by repressing cyclin D1 expression.
Developmental cell - 1 Jul 2003
Toyoda Masashi, Shirato Haruki, Nakajima Kuniko, Kojima Mizuyo, Takahashi Miho, Kubota Misae, Suzuki-Migishima Rika, Motegi Yoshiko, Yokoyama Minesuke, Takeuchi Takashi
Abstract excerpt
Spatiotemporal regulation of cell proliferation is necessary for normal tissue development. The molecular mechanisms, especially the signaling pathways controlling the cell cycle machinery, remain largely unknown. Here, we demonstrate a negative relationship between the spatiotemporal patterns of jumonji (jmj) expression and cardiac myocyte proliferation. cyclin D1 expression and cell proliferation are enhanced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.