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Article

α-SNAP and NSF are required in a priming step during the human sperm acrosome reaction

13 Nov 2004

Abstract excerpt

The acrosome is a membrane-limited granule that overlies the nucleus of the mature spermatozoon. In response to physiological or pharmacological stimuli it undergoes a special type of Ca2+-dependent exocytosis termed the acrosome reaction (AR), which is an absolute prerequisite for fertilization. Aided by a streptolysin-O permeabilization protocol developed in our laboratory, we have previously demonstrated...

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PMID: 15542541
DOI: 10.1093/molehr/gah126

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