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Acrosomal Swelling and Membrane Docking Are Required for Hybrid Vesicle Formation During the Human Sperm Acrosome Reaction1

15 Apr 2009

Abstract excerpt

Acrosomal exocytosis in mammalian sperm is a regulated secretion with unusual characteristics. One of its most striking features is the loss of the outer acrosomal membrane and the overlying plasma membrane as hybrid vesicles. We have reported previously in human sperm that by preventing the release of calcium from the acrosome, the exocytic process can be arrested at a stage where SNARE proteins are assembled in...

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PMID: 19369646
DOI: 10.1095/biolreprod.109.076166

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