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Article

Calcineurin-mediated dephosphorylation of synaptotagmin VI is necessary for acrosomal exocytosis.

The Journal of biological chemistry - 20 Aug 2010

Castillo Bennett Jimena, Roggero Carlos M, Mancifesta Franco E, Mayorga Luis S

Abstract excerpt

Regulated secretion is a fundamental process underlying the function of many cell types. In particular, acrosomal exocytosis in mammalian sperm is essential for egg fertilization. In general, exocytosis is initiated by a cytosolic calcium increase. In this report we show that calcium affects several factors during human sperm acrosomal exocytosis. By using an antibody that specifically recognizes synaptotagmin VI...

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Source

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Identifiers

PMID: 20551332
DOI: 10.1074/jbc.M109.095752
PMCID: PMC2924044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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