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Article

Epac, Rap and Rab3 act in concert to mobilize calcium from sperm’s acrosome during exocytosis

26 Aug 2014

Abstract excerpt

BACKGROUND: Exocytosis of sperm's single secretory granule or acrosome (acrosome reaction, AR) is a highly regulated event essential for fertilization. The AR begins with an influx of calcium from the extracellular milieu and continues with the synthesis of cAMP and the activation of its target Epac. The cascade bifurcates into a Rab3-GTP-driven limb that assembles the fusion machinery and a Rap-GTP-driven limb...

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PMID: 25159528
DOI: 10.1186/s12964-014-0043-0

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