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Article

α-SNAP Prevents Docking of the Acrosome during Sperm Exocytosis because It Sequesters Monomeric Syntaxin

18 Jul 2011

Abstract excerpt

α-SNAP has an essential role in membrane fusion that consists of bridging cis SNARE complexes to NSF. α-SNAP stimulates NSF, which releases itself, α-SNAP, and individual SNAREs that subsequently re-engage in the trans arrays indispensable for fusion. α-SNAP also binds monomeric syntaxin and NSF disengages the α-SNAP/syntaxin dimer. Here, we examine why recombinant α-SNAP blocks secretion in permeabilized human...

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PMID: 21789195
DOI: 10.1371/journal.pone.0021925

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

α-SNAP Prevents Docking of the Acrosome during Sperm Exocytosis because It Sequesters Monomeric SyntaxinPMID 21789195Read ↗

The molecular chaperone cysteine string protein is required for monomeric SNARE proteins to assemble intrans-complexes during human sperm acrosomal exocytosisSemantic proximity Read ↗

α-SNAP and NSF are required in a priming step during the human sperm acrosome reactionSemantic proximity Read ↗

The molecular chaperone Cysteine String Protein is required to stabilize <i>trans</i> -SNARE complexes during human sperm acrosomal exocytosisSemantic proximity Read ↗

The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice.Semantic proximity Read ↗

A pathogenic mutation in α-SNAP impairs membrane lipid binding by concealing a critical hydrophobic loop.Semantic proximity Read ↗

A conserved membrane attachment site in alpha-SNAP facilitates N-ethylmaleimide-sensitive factor (NSF)-driven SNARE complex disassembly.Semantic proximity Read ↗

How Pig Sperm Prepares to Fertilize: Stable Acrosome Docking to the Plasma MembraneSemantic proximity Read ↗

Gβγ inhibits exocytosis via interaction with critical residues on soluble N-ethylmaleimide-sensitive factor attachment protein-25.Semantic proximity Read ↗

α-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility.Semantic proximity Read ↗

SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion.Semantic proximity Read ↗

Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex.Semantic proximity Read ↗

The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis.Semantic proximity Read ↗

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