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Article

Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis

2 Jul 2012

Abstract excerpt

Two so-called "secretory Rabs," Rab3 and Rab27, regulate late steps during dense-core vesicle exocytosis in neuroendocrine cells. Sperm contain a single large dense-core granule that is released by regulated exocytosis (termed the acrosome reaction) during fertilization or on exposure to inducers in vitro. Sperm exocytosis uses the same fusion machinery as neurons and neuroendocrine cells, with an additional...

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PMID: 22753498
DOI: 10.1073/pnas.1121173109

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