Article
Genomic heterogeneity and instability in colorectal cancer: spectral karyotyping, glutathione transferase-Ml and ras.
Mutation research - 21 Dec 2004
Bartos Jeremy D, Stoler Daniel L, Matsui Sei-ichi, Swede Helen, Willmott Lyndsay J, Sait Sheila N, Petrelli Nicholas J, Anderson Garth R
Abstract excerpt
Genomic instability in cancer is frequently described as being either chromosomal instability or microsatellite instability, although when events within chromosomes are monitored, extensive intrachromosomal instability is also found. Spectral karyotyping was used to visualize how extensively genomic instability gives rise to intratumor genomic heterogeneity in sporadic colorectal carcinomas. Two factors were then...
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