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Article

Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant.

Molecular biology of the cell - 1 May 2006

Green Brian M, Morreale Richard J, Ozaydin Bilge, Derisi Joseph L, Li Joachim J

Abstract excerpt

To maintain genomic stability, reinitiation of eukaryotic DNA replication within a single cell cycle is blocked by multiple mechanisms that inactivate or remove replication proteins after G1 phase. Consistent with the prevailing notion that these mechanisms are redundant, we previously showed that simultaneous deregulation of three replication proteins, ORC, Cdc6, and Mcm2-7, was necessary to cause detectable...

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Identifiers

PMID: 16481397
DOI: 10.1091/mbc.e05-11-1043
PMCID: PMC1446083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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