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Article

Effect of pioglitazone on the early stage of type 2 diabetic nephropathy in KK/Ta mice.

Metabolism: clinical and experimental - 1 Nov 2004

Tanimoto Mitsuo, Fan Qiuling, Gohda Tomohito, Shike Toshihide, Makita Yuichiro, Tomino Yasuhiko

Abstract excerpt

Pioglitazone (PIO) has preventive effects on impaired glucose tolerance (IGT) and urinary albumin excretion in diabetes. These effects in the early stage of diabetic nephropathy have not been fully described. Endothelial constitutive nitric oxide synthase (ecNOS) might be one of the mechanisms of glomerular hyperfiltration. The objective of the present study was to evaluate the effect of PIO, including the role...

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PMID: 15536604
DOI: 10.1016/j.metabol.2004.06.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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