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Article

A variant 2677A allele of the MDR1 gene affects fexofenadine disposition.

Clinical pharmacology and therapeutics - 1 Nov 2004

Yi So-Young, Hong Kyoung-Sup, Lim Hyeong-Seok, Chung Jae-Yong, Oh Dal-Seok, Kim Jung-Ryul, Jung Hye-Ryung, Cho Joo-Youn, Yu Kyung-Sang, Jang In-Jin, Shin Sang-Goo

Abstract excerpt

BACKGROUND AND OBJECTIVES: There have been considerable disagreements regarding the influence of MDR1 (ABCB1) polymorphisms on the disposition of P-glycoprotein (P-gp) substrates. We speculated that the unknown function of the A allele of exon 21 G2677T/A (Ala893Ser/Thr) provides one of the reasons for the contradictory results. This study was performed to clarify the effects of major MDR1 gene polymorphisms,...

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Source

Identifiers

PMID: 15536457
DOI: 10.1016/j.clpt.2004.08.002

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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