Article
Identification of functionally variant MDR1 alleles among European Americans and African Americans.
Clinical pharmacology and therapeutics - 1 Aug 2001
Kim R B, Leake B F, Choo E F, Dresser G K, Kubba S V, Schwarz U I, Taylor A, Xie H G, McKinsey J, Zhou S, Lan L B, Schuetz J D, Schuetz E G, Wilkinson G R
Abstract excerpt
MDR1 (P-glycoprotein) is an important factor in the disposition of many drugs, and the involved processes often exhibit considerable interindividual variability that may be genetically determined. Single-strand conformational polymorphism analysis and direct sequencing of exonic MDR1 deoxyribonucleic acid from 37 healthy European American and 23 healthy African American subjects identified 10 single nucleotide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.