Article

ATF4 mediates fetal globin upregulation in response to reduced β-globin

2020-01-15

Abstract excerpt

Fetal development and anemias such as β-hemoglobinopathies trigger rapid production of red blood cells in a process known as stress erythropoiesis. Cellular stress prompts differentiating erythroid precursors to express high levels of fetal γ-globin, which has suggested strategies to treat hemoglobinopathies such as thalassemia and sickle cell disease. However, the mechanisms underlying γ-globin production during...

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Literature Corpus work: aa4d72fc-87bb-505a-9cc1-7046b249af31
DOI: 10.1101/2020.01.15.905943

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