Alteration of tumor phenotypes of B16 melanoma after genetic remodeling of the ganglioside profile.

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Article

Alteration of tumor phenotypes of B16 melanoma after genetic remodeling of the ganglioside profile.

International journal of oncology - 1 Jul 2000

Tsurifune T, Ito T, Li X J, Yamashiro S, Okada M, Kanematsu T, Shiku H, Furukawa K

Abstract excerpt

Gangliosides have been thought to be tumor markers of various neuroectoderm-derived cancers. However, their roles in malignant phenotypes of cancer cells are not well understood. We have performed the remodeling of ganglioside profiles of mouse melanoma B16 (B78 subline) by introducing GM2/GD2 synthase cDNA, and analyzed the phenotypic changes such as cell morphology, growth, adhesion and c-fos gene expression....

Topics

Animals
Cell Division
G(M2) Ganglioside
Gangliosides
Genes, fos
Integrins
Melanoma, Experimental
Mice
N-Acetylgalactosaminyltransferases
Phenotype
Recombinant Proteins
Transfection
Tumor Cells, Cultured
Polypeptide N-acetylgalactosaminyltransferase

Source

Open in PubMed

Identifiers

PMID: 10853034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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